A pile-supported breakwater with perforated inclined wave screen is proposed and its wave-dissipating performance under the action of regular wave is studied through physical model experiments. The changes of the wave surface of the breakwater at both the wave-ward side and the back wave side are observed during the experiments, the influences of the open-pore rateεand combination B of the wave screen of the breakwater on the wave-dissipating performance under different incident wave conditions are discussed, the relations of the wave reflection coefficient，transmission coefficient and wave-dissipating coefficient of the breakwater to the relative wave height H/D and relative breakwater width W/L are analyzed and the wave-dissipating mechanism of this type of breakwater is analyzed from the point of view of the wave energy distribution. The results show that in the case of a single perforated inclined wave screen the average transmission coefficient can be reduced by 24.3% and the average wave-dissipating coefficient can be increased by 12.8% when the open-pore rate of the wave screen decreases from 30% down to 10%. In the case of double perforated inclined wave screens, the reflection coefficient of the breakwater depends on the open-pore rate of the front wave screen and the transmission coefficient relies on the minimum open-pore rate of the combined wave screens.